From Logan airport, we highly recommend taking a taxi. You can also take the subway, called the T in Boston. You can find general information at www.mbta.com.
To get to the hotel from the airport, catch the subway bus to the airport terminal. Take the Blue line to Government center; switch to the Green Line, to Park Street; switch to the Red Line, to Central Square. The hotel is just a few blocks from the Central Square station. (And just a bit further from the Kendall/MIT station.)
To get to MIT CSAIL from the airport, do everything as though you were going to hotel (above), but get off at the Kendall/MIT station.
Also, see Directions to CSAIL and Directions to Le Meridien Hotel.
It may also be possible to fly into other nearby airports, such as Providence, which has bus service to the South Station T stop, on the Red Line. (The bus takes a little over 1 hour; then take the Red Line to Central Square..)Trains from New York also arrive at the South Station T stop, on the Red Line. (Take the Red Line to Central Square.)
Lots of dining -- see list of recommended restaurants (in progress) AND DiscoverOurTown.com
What's for lunch in Kendall Square
Other local interest links
City info for Cambridge
City info for Boston
Boston Duck Tours
New England Aquarium
Boston Symphony Hall
Faneuil Hall/Quincy Market
Outdoor concerts in the hatch shell
Boston North End
Boston Museum of Science
Boston Museum of Fine Arts
Boston Beacon Hill
Boston Common and start of Freedom Trail
Boston Public Garden and Swan boats
Boston Harbor Islands
Boston Harbor Cruises
Boston Harbor Cruises to Provincetown, Cape Cod
Lots of universities and colleges in the area including Harvard, Tufts, Northeastern, UMass Boston, Boston College, Simmons, etc.