À la Une

Soutenance de thèse Julien Mariethoz


M. Julien Mariethoz soutiendra en anglais, en vue de l'obtention du grade de docteur ès sciences, mention bioinformatique, sa thèse intitulée:

Heterogeneous Data Processing for Information and Knowledge Management in Glycomics and Glycoproteomics

Date: Vendredi 4 mars 2022 à 10h00

Lieu: Battelle A, Auditoire rez-de-chaussée, ou sur zoom


Jury :

  • Prof. Kiyoko Aoki-Kinoshita (Soka University, Tokyo, Japan), 
  • Prof. Daniel Bojar (University of Gothenburg, Sweden), 
  • Prof. Amos Bairoch, (SIB Swiss Institute of Bioinformatics and Faculty of Medicine, University of Geneva), 
  • Prof. Bastien Chopard, (SIB Swiss Institute of Bioinformatics and Faculty of Sciences, University of Geneva)   
  • Dr. Frédérique Lisacek, PhD supervisor (SIB Swiss Institute of Bioinformatics and Faculty of Sciences, University of Geneva)


Glycans or carbohydrates represent a major class of biomolecules. They are also the observable result of the most common \acrlong{ptm}, known to play a crucial role in the host-pathogen interactions as well as in signaling processes or disease states, among others. 

Glycoinformatics is the dedicated bioinformatics field supporting glycobiology and its experimental parts, including glycomics and glycoproteomics and any other glycan-oriented studies. The generated data and resulting information drive the discipline. 

Glycans molecules have tree structures with a characterized topology. This structural complexity induces glycoinformatics problems relative to their representation, encoding formats, processing, and interpretation. Furthermore, the lack of consensus in this respect significantly limits reproducibility and comparability in glycobiology. We suggest that common descriptions,  application guidelines, and best practices are solutions to overcome these issues.

Over the recent years, FAIR principles and MIRAGE (minimum information required for a glycomics experiment) initiative have driven and ruled data standardization processes. Subsequently, adopting these principles and guidelines improves reproducibility, interoperability, and data reuse, increasing its value.

Based on published articles, this thesis globally covers different specificities of glycans, their representation, and current field knowledge, where a common approach is needed. Several glycoinformatics resources are presented.