À la Une

Soutenance de thèse Oliver Horlacher

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M. Oliver Horlacher soutiendra en anglais, en vue de l'obtention du grade de docteur ès sciences, mention bioinformatique, sa thèse intitulée:

Developing Algorithms to Automate the Identification of Post Translational Modification in LC-MS/MS Data

 

Date: Mardi 27 février 2018 à 14h00

Lieu: CMU - auditoire de pédiatrie - 45 avenue de la Roseraie

 

Jury:

  • Dr. Frédérique Lisacek (Directrice de thèse, Université de Genève)
  • Prof. Bastien Chopard (Université de Genève)
  • Prof. Sviatoslav Voloshynovskyy  (Université de Genève)
  • Dr. Markus Müller (Université de Genève)
  • Dr. Stuart Haslam (Imperial College London)

Résumé:

Understanding post-translational modification (PTM) of proteins and how PTMs influences cellular processes is an important part of understanding the biology of both healthy and diseased cells. The most widely used experimental technique for studying PTMs is Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). When LC-MS/MS is applied to complex mixtures, such as cell lines or tissue samples, a large amount of raw data is produced which needs to be analysed to identify molecular structures.

This thesis focuses on the development of software to automate the
identification of PTMs in proteomic MS/MS data and identifying glycans in glycomic MS/MS data.

The outcome of this thesis are three software packages: MzJava, MzMod and Glycoforest.

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