À la Une

Soutenance de thèse Davide Alocci

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M. Davide Alocci soutiendra en anglais, en vue de l'obtention du grade de docteur ès sciences, mention bioinformatique, sa thèse intitulée:

An Interactive and Integrative View of Glycobiology

Date: Vendredi 28 septembre 2018 à 14h30

Lieu: CMU - 1, rue Michel Servet - Auditoire C150

 

Sous la direction de:

  • Dr. Frédérique Lisacek

Résumé:

Glycosylation is one of the most abundant post-translational modifications (PTM) and the primary cause of microheterogeneity in proteins (glycoforms). It consists of the addition of a sugar moiety on the surface of a protein, and it has been suggested that over 50% of mammalian cellular proteins are typically glycosylated.

Despite its importance, glycobiology is still lacking concrete bioinformatics support which, in the last two decades, has boosted other major ’omics’ like proteomics, tran- scriptomics and genomics. Additionally, the inherent complexity of carbohydrates and the use of many orthogonal experimental techniques to elucidate a structure have slowed down the annotation of novel glycans leaving glycobiology fragmented internally.

This thesis aims at the creation of a collection of tools to reconstitute the puzzle of biological evidence produced by different glycomics experiments and, at the same time, fill the gap with other ’omics’.

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